The current delivery of Polynucleotides with Micro needling for practitioners in the United States versus Europe and Asia. By Deborah Winter, RN.
Microneedling combined with the application of Polydeoxyribonucleotide (PDRN) has emerged as an increasingly popular treatment modality in the United States. This is often described as The Salmon Sperm Facial (The PDRN is harvested from fish gonads) and is administered through the micro channel created during microneedling.
PDRN is a bioactive compound derived from DNA fragments extracted from salmon sperm. It has exhibited significant anti-inflammatory and skin-brightening effects by inhibiting melanin production and fostering tissue repair. Numerous preclinical and clinical studies have validated the diverse properties of PDRN, including its anti-inflammatory, anti-melanogenic, regenerative, tissue damage preventive, anti-ulcerative, and wound healing capabilities (Kim et al., 2022; Sun et al., 2023).
The scientist research is explained as follows:
. Anti-inflammatory: Reduces inflammation.
Anti-apoptotic: Helps prevent cell death.
Anti-osteoporotic: Protects against bone loss.
Anti-melanogenetic: Inhibits excessive skin pigmentation.
Anti-allodynic: Alleviates pain from normally non-painful stimuli.
Anti-osteonecrotic: Helps prevent bone tissue death.
Microneedling devices, such as the SkinPen™, create micro-channels at a frequency of 1,600 per second, stimulating the immune system to enhance blood circulation, and initiate the formation of new tissue. During the proliferation phase, a network of new blood vessels is formed, allowing the micro-wounds to heal with granulation cells rich in collagen proteins. Finally, during the remodeling phase, the micro-wounds are reconstructed with fresh dermal tissue and blood vessels composed of collagen and elastin proteins (Crown Aesthetics, 2025).
Recent studies have underscored the potential of microneedling to improve the transdermal delivery of various therapeutics by bypassing the stratum corneum and facilitating direct access to the vascularized dermis. Notably, this technique has been shown to significantly expand the follicular infundibulum by 47%, potentially enhancing the penetration of medications through the skin barrier (Litchman G, Nair PA, Badri T, et al.).
When these two treatment modalities are employed in tandem, the micro-channels created by microneedling facilitate the penetration of PDRN into the deeper layers of the skin. It is important to note that while PDRN injections are approved for use in Europe and are preferred in that context, the FDA has yet to authorize its injectable form in the United States.
In this region, practitioners predominantly utilize microneedling to administer PDRN, presenting specific challenges in the delicate under-eye area due to the proximity of blood vessels to the skin's surface. Mastery of needle precision is essential, and nano needles while micro needling are employed to delicately access this sensitive region.
Three treatments of PDRN through microneedling effectively thicken the dermis, rendering superficial blood vessels beneath the eyes—often responsible for dark shadows—no longer visible. This approach requires no fillers or lasers, as regenerative fragments of DNA work synergistically with the body's own cells to repair and remodel the skin.
For the cheek area, microneedling combined with PDRN application in the lower quadrant enhances volume and rejuvenates sagging skin. Additionally, cell repair mechanisms help mitigate the long-term effects of sun damage, significantly reducing the appearance of past sunburns.
While microneedling has some benefits to injections, a combination of the two techniques would be preferred. For the past two years, I have dedicated myself to mastering this technique of injections in the UK and have traveled back to London multiple times to refine my skills further in preparation for offering this advanced treatment. I am committed to providing PDRN microneedling services upon FDA approval of Nutrophil, the leading manufacturer from Italy, which will enhance the options available for effective skin rejuvenation.
Khan, A., Wang, G., Zhou, F., Gong, L., Zhang, J., Qi, L., & Cui, H. (2022). Polydeoxyribonucleotide: A promising skin anti-aging agent. Chinese Journal of Plastic and Reconstructive Surgery, 4(4), 187-193.
Litchman G, Nair PA, Badri T, et al. Microneedling. [Updated 2022 Sep 26]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2026 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK459344/